Quality Control of 3,4-Dimethylbenzonitrile, Career opportunities within science and technology are seeing unprecedented growth across the world, and those who study chemistry or another natural science at university now have increasingly better career prospects. 22884-95-3, Name is 3,4-Dimethylbenzonitrile, SMILES is CC1=C(C)C=C(C=C1)C#N, belongs to isothiazole compound. In a article, author is GAROZZO, A, introduce new discover of the category.
In this report we describe the antiviral activity of 5,5′-diphenyl-3,3’diisothiazole disulfide (DID) and discuss its mode of action. DID selectively inhibits the replication of poliovirus type 1 (therapeutic index = 255) by affecting some early process of the virus growth cycle. The compound does not interfere with adsorption and internalization of virus to HEp-2 cells, nor with uncoating of the viral RNA. However, no viral RNA synthesis occurs after 2 h postinfection in the presence of 50 mu M DID. Thus, we investigated some molecular events in poliovirus replication occurring between uncoating and viral RNA synthesis. In our experimental design, we studied the activity of RNA polymerase complex isolated from HEp-2 infected cells in the presence or absence of DID. Our results showed that the RNA polymerase complex was formed in the presence of DID, On the contrary, DID markedly inhibited poliovirus RNA synthesis in a cell-free system using RNA polymerase complex isolated from infected cells. These findings indicate that DID may exert its antiviral activity by preventing viral RNA chain elongation via the inhibition of replicase activity and/or interfering with viral RNA polymerase complex.
Future efforts will undeniably focus on the diversification of the new catalytic transformations. These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. Keep reading other articles of 22884-95-3. Quality Control of 3,4-Dimethylbenzonitrile.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com