Healthcare careers for chemists are once again largely based in laboratories, although increasingly there is opportunity to work at the point of care, helping with patient investigation.586-76-5, Name is 4-Bromobenzoic acid, molecular formula is C7H5BrO2, belongs to isothiazole compound. In a document, author is Potkin, V. I., introduce the new discover, Electric Literature of 586-76-5.
Acylation of vanillin with isonicotinoyl chloride gave 4-formyl-2-methoxyphenyl pyridine-4-carboxylate which was converted into a number of functional derivatives, including those containing isoxazole and isothiazole heterocycles. In particular, the condensation of the title compound with primary amines afforded the corresponding Schiff bases. 4-Formyl-2-methoxyphenyl pyridine-4-carboxylate and one of the Schiff bases derived therefrom were reduced with sodium triacetoxohydridoborate to the corresponding alcohol and amine which were acylated with 5-arylisoxazole- and 4,5-dichloroisothiazole-3-carbonyl chlorides to obtain esters and amides having isoxazole and isothiazole fragments. The synthesized compounds readily formed complexes with palladium(II) chloride, which showed a high catalytic activity in the Suzuki reaction of 3-bromobenzoic acid with 4-methoxyphenylboronic acid in water in the absence of an organic solvent.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield. If you are hungry for even more, make sure to check my other article about 586-76-5, Electric Literature of 586-76-5.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com