Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment. 114772-54-2, Name is 4′-(Bromomethyl)-[1,1′-biphenyl]-2-carbonitrile, molecular formula is C14H10BrN, SDS of cas: 114772-54-2, belongs to isothiazole compound, is a common compound. In a patnet, author is PINIZZOTTO, MR, once mentioned the new application about 114772-54-2.
The in vitro effects of four isothiazoles [5,5′-diphenyl-3,3′-diisothiazole disulfide, 5-phenyl-3-mercapto-isothiazole, 5,5′-(4-chlorophenyl)-3,3′-diisothiazole disulfide, and 5-(4-chlorophenyl)-3-mercapto-isothiazole] on poliovirus type 1 were studied. The derivatives tested demonstrated remarkable viral inhibition, with a higher selectivity index than the previously studied iminodithiole precursors. Under one-step growth conditions, all the isothiazole derivatives caused the greatest activity if added during or after (within 1 h) pollovirus adsorption. These data suggest interference with early events of viral replication. [5-H-3]Uridine incorporation into RNA showed that the compounds tested reduced pollovirus RNA synthesis, which was completely shut off after 2 h of incubation and reduced by 50-60% after 4 h. Also, pretreatment of the cell cultures with the compounds for 24 h caused a substantial inhibition of viral replication. The data suggest that the four isothiazole derivatives may have a multi-step antiviral mode of action different from their iminodithiole precursors.
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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com