New Advances in Chemical Research, April 2021. Product Details of 22884-95-3, Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. 22884-95-3, Name is 3,4-Dimethylbenzonitrile, SMILES is CC1=C(C)C=C(C=C1)C#N, belongs to isothiazole compound. In a article, author is Mihara, Gen, introduce new discover of the category.
A Rh(III)-catalyzed annulative coupling of 3,5-diarylisothiazoles and alkynes is reported. The N-S bond in the isothiazole ring acts as an internal oxidant to regenerate the Rh(III) species in combination with an external Cu(II) oxidant, and the corresponding 1:2 coupling products are obtained. The remarkable difference in the reaction outcome between isothiazoles and the relevant isoxazoles has been investigated by DFT calculations, revealing that the relative stability of the enolate intermediates dictates the product selectivity.
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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com