Healthcare careers for chemists are once again largely based in laboratories, although increasingly there is opportunity to work at the point of care, helping with patient investigation.127-63-9, Name is Sulfonyldibenzene, molecular formula is C12H10O2S, belongs to isothiazole compound. In a document, author is FROLUND, B, introduce the new discover, Computed Properties of https://www.ambeed.com/products/127-63-9.html.
The synthesis of tritium labelled thiomuscimol (5-amino[H-3](2)methyl-3-isothiazolol) (7c), a specific and high-affinity agonist photoaffinity label for GABA(A) receptors, is described. The synthesis of 7c is based on a procedure for the preparation of 5-amino[H-2](2)methyl-3-isothiazolol (7b). Methyl 3-ethoxyisothiazole-5-carboxylate (3), synthesized from 3-hydroxyisothiazole-5-carboxamide (1) via the corresponding methyl ester (2), was reduced with sodium borotritide to give 3-ethoxy-5-hydroxy[H-3](2)-methyl-3-isothiazole (4c). 3-Ethoxy-5-phthalimido[H-3](2)- methylisothiazole (6c), synthesized from the 5-chloro[H-3](2)methyl analogue (5c) of (4c), was deprotected by treatment with concentrated hydrochloric acid to give 7c with a specific radioactivity of 29 Ci/mmol. In pilot binding assays, 7c was shown to bind to membranes from rat forebrain in a saturable manner and with K-D and B-max values of 28 +/- 6 nM and 50 +/- 4 fmol/mg original tissue, respectively.
Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.In my other articles, you can also check out more blogs about 127-63-9. Computed Properties of https://www.ambeed.com/products/127-63-9.html.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com