New discoveries in chemical research and development in 2021, Some examples of the diverse research done by chemistry experts include discovery of new medicines and vaccines, and development of new chemical products and materials. 35285-69-9, Name is Sodium 4-(propoxycarbonyl)phenolate, SMILES is [O-]C1=CC=C(C(OCCC)=O)C=C1.[Na+], in an article , author is Hao, Junliang, once mentioned of 35285-69-9, SDS of cas: 35285-69-9.
A novel series of selective negative allosteric modulators (NAMs) for metabotropic glutamate receptor 5 (mGlu5) was discovered from an isothiazole scaffold. One compound of this series, (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide (24), demonstrated satisfactory pharmacokinetic properties and, following oral dosing in rats, produced dose-dependent and long-lasting mGlu5 receptor occupancy. Consistent with the hypothesis that blockade of mGlu5 receptors will produce analgesic effects in mammals, compound 24 produced a dose-dependent reduction in paw licking responses in the formalin model of persistent pain. (c) 2013 Elsevier Ltd. All rights reserved.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 35285-69-9. SDS of cas: 35285-69-9.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com