New research progress on 92-91-1 in 2021. Career opportunities within science and technology are seeing unprecedented growth across the world, and those who study chemistry or another natural science at university now have increasingly better career prospects. 92-91-1, Name is 1-([1,1′-Biphenyl]-4-yl)ethanone, formurla is C14H12O. In a document, author is Bunch, L, introducing its new discovery. Safety of 1-([1,1′-Biphenyl]-4-yl)ethanone.
Direct functionalization of the 3-oxygenated isothiazole heteroaromatic parental system has not yet been reported in the literature. Here, we report the first regioselective lithiation of the 5-position of 3-(benzyloxy)isothiazole (4) using LDA in diethyl ether. The versatility of the methodology was explored by quenching with a variety of electrophiles to give the desired products 7a,b,d-g in 54-68% yield. Only benzoylation aiming at the synthesis of 7c was unsuccessful. Furthermore, a highly convergent synthesis of thioibotenic acid (1), the sulfur analogue of the neurotoxic natural product ibotenic acid, was carried out.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 92-91-1. Safety of 1-([1,1′-Biphenyl]-4-yl)ethanone.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com