Chemical Research Letters, April 2021. Chemical engineers ensure the efficiency and safety of chemical processes, adapt the chemical make-up of products to meet environmental or economic needs, and apply new technologies to improve existing processes. 114772-54-2, Name is 4′-(Bromomethyl)-[1,1′-biphenyl]-2-carbonitrile, molecular formula is C14H10BrN, Safety of 4′-(Bromomethyl)-[1,1′-biphenyl]-2-carbonitrile, belongs to isothiazole compound, is a common compound. In a patnet, author is Mishra, Vaibhav, once mentioned the new application about 114772-54-2.
Twenty-two compounds in a series of 1-(benzo[b]thiophen-4-yl)-4-(2-(oxo, hydroxy, and fluoro)-2-phenylethyl) piperazine and 1-(benzo[d]isothiazole-3-yl)-4-(2-(oxo, hydroxy, and fluoro)-2-phenylethyl)-piperazine derivatives were synthesized through nucleophilic substitution reaction of phenacyl bromides with hetero arylpiperazine, reduction, and then fluorination. Compound K2 showed potent activity against gram-negative bacterial stain P. aeruginosa with minimum inhibitory concentration (MIC) value of 12.5 mu g/mL. This compound showed better inhibitory activity than the standard drug chloramphenicol. K4 against S. aureus, H2 against P. aeruginosa, and F4 against E. coli showed good inhibitory activity with MIC values of 62.5 mu g/mL. Compounds K1, K2, K4, K8, F1, and F3 showed good inhibitory activity against fungal stain C. albicans with MIC values of 250 mu g/mL. The crystal structure of F1 was determined by single-crystal XRD (CCDC 1832090).
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield. If you are hungry for even more, make sure to check my other article about 114772-54-2, Safety of 4′-(Bromomethyl)-[1,1′-biphenyl]-2-carbonitrile.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com