New Advances in Chemical Research, April 2021. COA of Formula: https://www.ambeed.com/products/1719-19-3.html, Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment.1719-19-3, Name is 2-Methyl-4-phenylbut-3-yn-2-ol, SMILES is CC(O)(C)C#CC1=CC=CC=C1, belongs to isothiazole compound. In a article, author is Zeng, Li-Fan, introduce new discover of the category.
Three new types of aryl diketo acid (ADK) isosteres were designed by conversion of the biologically labile 1,3-diketo unit into heteroaromatic motif such as isoxazole, isothiazole, or 1H-pyrazole to improve the physicochemical property of ADK-based HIV-1 integrase (IN) inhibitors. The synthesis of the heteroaromatic carboxylic acids was established by employing phenyl beta-diketoester or benzaldehyde as the starting material and 1,3-dipolar cycloaddition as the key reaction. Of the compounds tested, the 3-benzyloxyphenyl-substituted isoxazole carboxylic acid displayed the best IN inhibitory and antiviral activities, with N-hydroxylamidation enhancing the in vitro and in vivo potency. These findings are important for further optimization of ADK-based IN inhibitors. (c) 2008 Elsevier Ltd. All rights reserved.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 1719-19-3. COA of Formula: https://www.ambeed.com/products/1719-19-3.html.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com