New discoveries in chemical research and development in 2021, Chemistry involves the study of all things chemical – chemical processes, how they change and how they react in certain situations. 3034-86-4, Name is Methyl 4-ethynylbenzoate, SMILES is O=C(OC)C1=CC=C(C#C)C=C1, in an article , author is Assy, MG, once mentioned of 3034-86-4, Safety of Methyl 4-ethynylbenzoate.
Isothiocyanate 1 reacted with enaminone 2 to give thioamide 3 that cyclized by sodium hydroxide to pyrimidine 4 but cyclized by bromine to give isothiazole 5, pyrimidine 4 was transformed into thiopyranopyrimidines 7, 9 or 11 upon respective reaction with benzaldehyde, maleic acid, or maleic anhydride. Aminative cyclization of 4 yielded isothiazolopyrimidine 13. Reaction of 4 and ethyl bromoacetate or phenacyl bromides afforded thienopyrimidines 15a-b respectively. Oxidation of 4 yielded oxopyrimidine 16.
Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. If you are hungry for even more, make sure to check my other article about 3034-86-4, Safety of Methyl 4-ethynylbenzoate.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com