Chemical Research Letters, April 2021. With the volume and accessibility of scientific research increasing across the world, it has never been more important to continue building the reputation we’ve spent the past two centuries establishing. 28348-53-0, Name is Sodium isopropylbenzenesulfonate, molecular formula is C9H11NaO3S, SDS of cas: 28348-53-0, belongs to isothiazole compound, is a common compound. In a patnet, author is Amin, Kamelia M., once mentioned the new application about 28348-53-0.
The preparation of new quinazoline and benzo[d]isothiazole-based antitumor agents is described. The target compounds fall into three groups including the N-substituted derivatives 2a-d, the substituted amino derivatives 4-6a-d, and the dimeric compounds 7-9a,b. Docking study of the designed compounds into the ATP binding site of epidermal growth factor receptor (EGFR) tyrosine kinase was performed to compare the binding mode of these compounds to the known EGFR inhibitor, lapatinib. All compounds were tested, in vitro, for their activity against human mammary carcinoma cell line (MCF7) in which EGFR is highly expressed. All compounds showed significant growth inhibitory activity. The remarkable activity of the bis quinazoline derivative 8a (IC50 = 0.06 mu g/ml; 1.64 nmol/ml) is to be noted.
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. Interested yet? Keep reading other articles of 28348-53-0, you can contact me at any time and look forward to more communication. SDS of cas: 28348-53-0.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com