(3aS,6S,7aS)-8,8-Dimethylhexahydro-1H-3a,6-methanobenzo[c]isothiazole 2,2-dioxide, cas is 94594-90-8, it is a common heterocyclic compound, the isothiazole compound, its synthesis route is as follows.,94594-90-8
Take 30 g of the resulting intermediate, add 250 mL of dichloromethane. After stirring to clarify,37 g of camphorsulfonamide and 9. 6 g of N, N’-4-dimethylaminopyridine (DMAP) were added and the reaction was cooled to 10 ¡ã C. A solution of 75 g of N, N’-dicyclohexylcarbodiimide (DCC) and 50 mL of DCM was added dropwise, and the temperature of the dropping process was below 20 ¡ã C. After completion of the dropwise addition, the reaction was carried out at 20 ¡ã C to 25 ¡ã C for 18 hours. After completion of the reaction, the reaction solution was filtered and the resulting filtrate was washed once with 50 mL of water and once with 25 mL of saturated brine. After the dichloromethane phase was concentrated, 300 mL of n-heptane was added to precipitate a solid. Filtered and then dried to give 56 g of a solid, 99.8percent purity, 91percent yield.
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Reference£º
Patent; Dalian Honkai Chemical Development Co., Ltd; Sun, Liquan; Zhao, xinjun; Feng, Yan-shu; Gao, Hanrong; cornille, Fabrice; Canevotti, Renato; (12 pag.)CN106588841; (2017); A;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com