New Advances in Chemical Research, April 2021. Application of 209911-63-7, While the job of a research scientist varies, most chemistry careers in research are based in laboratories, where research is conducted by teams following scientific methods and standards. 209911-63-7, Name is 4′-(Dibromomethyl)-[1,1′-biphenyl]-2-carbonitrile, SMILES is N#CC1=CC=CC=C1C2=CC=C(C(Br)Br)C=C2, belongs to isothiazole compound. In a article, author is Amirhamzeh, Amirali, introduce new discover of the category.
Neuroinflammation has been implicated in pathophysiology of many neurodegenerative diseases. The p38 MAP kinase signaling pathway and COX-1 have active roles in initiation and perpetuation of neuroinflammatory process which have deteriorating effects on neurons. In order to develop new anti-neuroinflammatory compounds some 4-aryl-5-(methylthiophen-2-yl) isothiazoles and 5-aryl-4-(methylthiophen-2-yl)-1,2,3-thiadiazoles were synthesized. Docking studies have revealed that these structures could be potential mutual inhibitors of p38 alpha and COX-1 and could be considered for neuroprotective effects. In order to assess CNS penetrability of these compounds, a QSAR model of blood-brain barrier penetration has been developed and LogBB of compounds has been predicted. All compounds showed LogBB as greater than zero which indicates their potential CNS penetrability.
Application of 209911-63-7, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect. I hope my blog about 209911-63-7 is helpful to your research.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com