Simple exploration of 677304-75-5

677304-75-5 6-Bromobenzo[d]isothiazole-3-carboxylic acid 53401192, aisothiazole compound, is more and more widely used in various fields.

677304-75-5, 6-Bromobenzo[d]isothiazole-3-carboxylic acid is a isothiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,677304-75-5

The following procedure was used to prepare benzisothiazole fer/-butyl esters:Di-ferz’-butyldicarbonate (128 mmol) was added to a suspension of 6-bromo-l,2- benzisothiazole-3-carboxyIic acid (46.5 mmol) and 4-dimethylaminopyridine (4.26 mmol) in tert-buty alcohol (40.0 mL) and tetrahydrofuran (40.0 mL) and the reaction mixture was heated at 65 0C for 16 hours. There was vigorous carbon dioxide evolution which gradually subsided as the mixture become homogeneous. The reaction mixture was concentrated and the residue was dissolved in dichloromethane. The dichloromethane solution was filtered through silica gel (ca. 5Og) and the eluent was concentrated to provide the ester product in 99% yield.The following ester was prepared using this method:tert-Butyl S-brorno-l^-benzisothiazole-S-carboxylate. tert-Butyl -bromo-l^-benzisothiazole-S-carboxylate.

677304-75-5 6-Bromobenzo[d]isothiazole-3-carboxylic acid 53401192, aisothiazole compound, is more and more widely used in various fields.

Reference£º
Patent; MEMORY PHARMACEUTICALS CORPORATION; WO2007/56582; (2007); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com