Chemical Research Letters, April 2021. Healthcare careers for chemists are once again largely based in laboratories, although increasingly there is opportunity to work at the point of care, helping with patient investigation. 93-17-4, Name is 3,4-Dimethoxyphenylacetonitrile, molecular formula is C10H11NO2, HPLC of Formula: https://www.ambeed.com/products/93-17-4.html, belongs to isothiazole compound, is a common compound. In a patnet, author is Da Settimo, F, once mentioned the new application about 93-17-4.
Acetic acid derivatives of naphtho[1,2-dlisothiazole (NiT) were synthesized and tested as novel aldose reductase (ALR2) inhibitors. The parent compound 11 exhibited a fair inhibitory activity (IC50 = 10 mu M), which was enhanced by 2 orders of magnitude by introducing a second carboxylic group at position 4 (13 and 14: IC50 = 0.55 and 0.14 mu M, respectively). Substitution of the acetic acid function with an apolar group gave inactive (29) or poorly active (25, 26, 30) compounds, thus demonstrating that the 2-acetic group is involved in the enzyme pharmacophoric recognition while the 4-carboxylic moiety has only an accessory role. The potent compounds 11, 13, 14, 26 all proved to be selective for ALR2, since none of them inhibited aldehyde reductase, sorbitol dehydrogenase, or glutathione reductase. The isopropyl. ester 31, a prodrug of 14, was found to be effective in preventing cataract development in severely galactosemic rats, when administered as an eyedrop solution. The theoretical binding mode of 13 and 14, obtained by docking simulations into the ALR2 crystal structure, was fully consistent with the structure-activity relationships in the NiT series.
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. Interested yet? Keep reading other articles of 93-17-4, you can contact me at any time and look forward to more communication. HPLC of Formula: https://www.ambeed.com/products/93-17-4.html.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com