New Advances in Chemical Research, April 2021. Name: 1,3,5-Tris(4-aminophenyl)benzene, Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment.118727-34-7, Name is 1,3,5-Tris(4-aminophenyl)benzene, SMILES is NC1=CC=C(C2=CC(C3=CC=C(N)C=C3)=CC(C4=CC=C(N)C=C4)=C2)C=C1, belongs to isothiazole compound. In a article, author is Nakae, Koichi, introduce new discover of the category.
Natural products have contributed to the elucidation of biological mechanisms as well as drug discovery research. Even now, the expectation for natural products is undiminished. We screened prostaglandin release inhibitors that had no effect on in vitro cyclooxygenase activity derived from natural product sources and discovered pronqodine A. Using spectral analysis and total synthesis, the structure of pronqodine A was shown to be a benzo[d]isothiazole-4,7-dione analogue. Evaluation of the biological activity of pronqodine A revealed that the NAD(P)H dehydrogenase quinone 1 (NQO1) converted pronqodine A into a two-electron reductive form. The reductive form underwent autoxidation and reversed to its native form immediately with the generation of reactive oxygen species. Further investigations proved that pronqodine A inhibited cyclooxygenase enzyme activity only in the presence of NQO1. Pronqodine A acts as a potential bioreductive compound, inhibiting prostaglandin release in selectively activated NQO1-expressing cells.
Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. If you are hungry for even more, make sure to check my other article about 118727-34-7, Name: 1,3,5-Tris(4-aminophenyl)benzene.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com