Chemical Research Letters, April 2021. Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 398489-26-4, Name is tert-Butyl 3-oxoazetidine-1-carboxylate, molecular formula is C8H13NO3, Recommanded Product: tert-Butyl 3-oxoazetidine-1-carboxylate, belongs to isothiazole compound, is a common compound. In a patnet, author is Djukic, Maja B., once mentioned the new application about 398489-26-4.
Two new neutral ruthenium(II) complexes [Ru(eta(6)-p-cymene)Cl-2(1)] (3) and [Ru(eta(6)-p-cymene)Cl-2(2)] (4) (1=5-(phenylamino)-3-pyrrolidin-1-ylisothiazole-4-carbonitrile;2=3-morpholin-4-yl-5-(phenylamino)isothiazole-4-carbonitrile) have been synthesized and characterized using elemental analysis, IR, UV-Vis and NMR spectroscopy. The crystal structure was confirmed for complex3and both ligands. Examination of the interactions of ligands and complexes with CT-DNA (Calf Thymus DNA), as well as with HSA (Human Serum Albumin) revealed that ligands and complexes could interact with CT-DNA through intercalation and could bind strongly with HSA. Docking experiments toward DNA dodecamer indicate excellent accordance with experimental Delta G values. The cytotoxic activity of ligands and complexes was evaluated by MTT assay against HCT116 and HeLa tumoral cells. The complexes3and4showed good activity and selectivity on HCT116 cells. Neither of the tested compounds shows cytotoxic activity against a healthy MRC-5 cell line. Flow cytometry analysis showed the apoptotic death of the HCT116 cells with a cell cycle arrest in the S-phase.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 398489-26-4. Recommanded Product: tert-Butyl 3-oxoazetidine-1-carboxylate.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com