Chemical Research Letters, April 2021. Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 53242-76-5, Name is 2-(2-(4-Chlorophenyl)acetyl)benzoic acid, molecular formula is C15H11ClO3, Safety of 2-(2-(4-Chlorophenyl)acetyl)benzoic acid, belongs to isothiazole compound, is a common compound. In a patnet, author is Regiec, A., once mentioned the new application about 53242-76-5.
The main goal of our study was the synthesis and biological evaluation of 4-amino- and 4-[(4-chlorobenzoyl)amino]-1-methylimidazole N-substituted 5-carboxamides. Biological in vitro tests indicated their remarkable influence on some cellular immune and inflammatory responses compared with ibuprofen and leflunomide as reference drugs. The toxicity of the tested compounds on murine bone marrow cells was also determined. The anti-inflammatory activity of 4-[(4-chlorobenzoyl)amino]-5-[N-(4-chlorophenyl)]-1-methyl-5-imidazolecarboxamide (7a) was confirmed in vivo in the carrageenan-induced oedema test. Comparison of the biological activity of 7a with that of the isosteric isothiazole derivative MR-2/94 suggests that replacement of the isothiazole core ring system with an imidazole one resulted in a considerable lowering of toxicity while maintaining anti-inflammatory and immunotropic properties.
Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. If you are hungry for even more, make sure to check my other article about 53242-76-5, Safety of 2-(2-(4-Chlorophenyl)acetyl)benzoic acid.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com