New discoveries in chemical research and development in 2021, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 92-91-1, Name is 1-([1,1′-Biphenyl]-4-yl)ethanone, SMILES is CC(C1=CC=C(C2=CC=CC=C2)C=C1)=O, in an article , author is Bunch, L, once mentioned of 92-91-1, Recommanded Product: 92-91-1.
Direct functionalization of the 3-oxygenated isothiazole heteroaromatic parental system has not yet been reported in the literature. Here, we report the first regioselective lithiation of the 5-position of 3-(benzyloxy)isothiazole (4) using LDA in diethyl ether. The versatility of the methodology was explored by quenching with a variety of electrophiles to give the desired products 7a,b,d-g in 54-68% yield. Only benzoylation aiming at the synthesis of 7c was unsuccessful. Furthermore, a highly convergent synthesis of thioibotenic acid (1), the sulfur analogue of the neurotoxic natural product ibotenic acid, was carried out.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 92-91-1. Recommanded Product: 92-91-1.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com