(3aS,6S,7aS)-8,8-Dimethylhexahydro-1H-3a,6-methanobenzo[c]isothiazole 2,2-dioxide, cas is 94594-90-8, it is a common heterocyclic compound, the isothiazole compound, its synthesis route is as follows.,94594-90-8
In a round-bottomed flask, 80 g of (1S)-(-)-2,10-camphorsultam, 236.4 g of methyl tert-butyl ether, 2.27 g of 4-(dimethylamino)-pyridine and 41.36 g of triethylamine were placed, and to this, 63.46 g of capryloyl chloride was added dropwise at room temperature. After stirring for 1 hour, the reaction solution was added to a mixed solution of 7.75 g of 35percent hydrochloric acid and 200 g of water, and the organic layer was separated. The organic layer was washed with 25percent aqueous sodium hydroxide solution and subsequently with water, and concentrated under reduced pressure. Thus, 125.34 g of the titled compound was obtained (quality: 99.7percent measured by GC).Gas chromatography analysis was carried out using Shimadzu GC-14A (Column: 5percent Silicone OV-17 manufactured by GL Science, Detector: FID).
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Reference£º
Patent; Yamazaki, Shigeya; Hosoya, Takeshi; US2009/118542; (2009); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com