Chemical Research Letters, April 2021. Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 35271-74-0, Name is 3-(4-Chlorophenyl)pentanedioic acid, molecular formula is C11H11ClO4, Computed Properties of https://www.ambeed.com/products/35271-74-0.html, belongs to isothiazole compound, is a common compound. In a patnet, author is Kelemen, Zsolt, once mentioned the new application about 35271-74-0.
The investigation of the stability of several imidazol-2-ylidene analogue cyclic carbenes by an isodesmic reaction has revealed that the hitherto unknown oxazol-2-ylidene exhibits only slightly smaller stability than imidazol-2-ylidene, outperforming some of the already synthesized carbenes. Selenazol-2-ylidene also shows significant stability. The contribution of aromaticity to the stabilization has been analysed for the different five-membered ring carbenes, and was found to be relatively small for the oxygen containing systems. Investigation of possible reactivity/decomposition pathways reveals that properly substituted oxazol-2-ylidene is stable against dimerization. The thermodynamically feasible cycloreversion reaction yielding isocyanate and acetylene is prevented by a significant barrier, and furthermore with proper substitution (ring annellation) the ring can be stabilized thermodynamically as well. While in the presence of water a hydrolytic ring opening occurs; this reaction can be hindered if the water content of the reaction mixture is reduced to a few equivalents. This hydrolytic behaviour as well as the electrophilicity and nucleophilicity indices of several known nucleophilic carbenes were compared, revealing that oxazol-2-ylidene exhibits a reduced nucleophilicity with respect to imidazol-2-ylidene, while its electrophilicity is only slightly increased. This unique combination might result in unexpected (organo) catalytic activities, further expanding the colourful applications of NHCs.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. In my other articles, you can also check out more blogs about 35271-74-0. Computed Properties of https://www.ambeed.com/products/35271-74-0.html.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com