Chemical Research Letters, April 2021. Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 383-29-9, Name is 4,4′-Sulfonylbis(fluorobenzene), molecular formula is C12H8F2O2S, Safety of 4,4′-Sulfonylbis(fluorobenzene), belongs to isothiazole compound, is a common compound. In a patnet, author is Greenwood, JR, once mentioned the new application about 383-29-9.
(S)-2-Amino-3-(3-hydroxy-5-methylisoxazol-4yl)propionic acid (AMPA) is the prototypical selective agonist for the AMPA subtype of excitatory amino acid (glutamate) receptors. Several 3-hydroxyisoxazole analogues are known to have activity at this receptor, as do a number of other alanine-substituted heterocyclic phenols, the acidic heterocycles being bioisosteres for the omega-carboxylate moiety of glutamate. The increasingly diverse range of known AMPA agonists is reviewed, including a number of novel pyridazine-based analogues. By removal of a common glycine unit, the parent heterocycles 3hydroxy-4,5-dimethyl-isoxazole, 3-hydroxy-4,5-dimethyl-isothiazole, 4-methyl-5-isoxazolone, 3-hydroxy-4-methyl-1,2,5-thiadiazole, 2-methyl-3,5-dioxo-1,2,4-oxadiazolidine, 1-methyl uracil, 6-aza-1-methyl uracil, and 3-hydroxy-4-methyl-pyridazine 1-oxide are modelled as representative of the known omega-carboxylate bioisosteres. In addition, heterocyclic fragments of inactive hydantoin and 3,5-dioxotriazole quisqualate analogues, and pyridazinone fragments with derivatives of varying potency are considered. These structures and their conjugate bases are subjected to high level ab initio calculations up to G2(MP2) theory, and semi-empirical aqueous phase calculations using the AM1-SM2 model. Their tautomerism and aqueous pK(a) behaviour are studied in detail, and compared with experimental data. Molecular geometries and electrostatic potential-derived charge distributions are presented. Electrostatic properties at the Van der Waals surface are compared. Calculated properties are discussed with respect to structural requirements for AMPA receptor activity. Tridentate models of AMPA receptor binding are presented.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. In my other articles, you can also check out more blogs about 383-29-9. Safety of 4,4′-Sulfonylbis(fluorobenzene).
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com