New discoveries in chemical research and development in 2021, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 39515-51-0, Name is 3-Phenoxybenzaldehyde, SMILES is C1=C(C=CC=C1OC2=CC=CC=C2)C=O, in an article , author is Christoforou, IC, once mentioned of 39515-51-0, Product Details of 39515-51-0.
3,5-Dichloroisothiazole-4-carbonitrile 1 reacts with aryl- and methylboronic acids to give in high yields the 3-chloro-5-(aryl and methyl)-isothiazole-4-carbonitrile 2 regiospecifically. The reaction was optimized with respect to base, phase transfer agent and palladium catalyst. Suzuki coupling at C-5 was also achieved in high yield using potassium phenyltrifluoroborate. The regiospecificity of either coupling method is maintained with 3,5-dibromoisothiazole-4-carbonitrile 4 to give exclusively 3-bromo-5-phenylisothiazole-4-carbonitrile 5. Suzuki cross-coupling conditions applied to 3-chloro-5-phenylisothiazole-4-carbonitrile 2a gave 3-phenoxy-5-phenylisothiazole-4-carbonitrite 6, which was prepared independently, and not the 3-phenyl derivative. All isothiazole products were fully characterized.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield. If you are hungry for even more, make sure to check my other article about 39515-51-0, Product Details of 39515-51-0.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com