2,3-Dihydrobenzo[d]isothiazole 1,1-dioxide, cas is 936-16-3, it is a common heterocyclic compound, the isothiazole compound, its synthesis route is as follows.,936-16-3
Example 27. 4-(1,1-Dioxido-1,2-benzisothiazol-2(3H)-yl)-2-piperazin-1-ylquinazoline. 2,4-Dichloroquinazoline (60 mg, 0.30 mmol), 2,3-dihydro-l,2-benzisothiazole 1,1-dioxide (50 mg, 0.30 mmol) and sodium hydride (11 mg, 0.45 mmol) were dissolved in anhydrous DMF (2 ml). The mixture was heated at 60¡ã C under nitrogen atmosphere for 10 min. Piperazine (52 mg, 0.60 mmol) was added and the heating was continued for 10 minutes. 5 The reaction mixture was diluted with water (0.5 ml), filtered and purified by preparative HPLC to give the acetate of the title compound as a solid (36 mg, 27 percent). 1H NMR (400 MHz, MeOD-d4) delta ppm 8.49 (1 H3 d) 7.58 – 7.87 (6 H, m) 730 – 7.38 (1 H, m) 5.58 (2 H, s) 4.03 – 4.16 (4 H3 m) 3.15 – 3.26 (4 H3 m); ESI-MS m/z M+H+ 382.
As the rapid development of chemical substances, we look forward to future research findings about 936-16-3
Reference£º
Patent; ASTRAZENECA AB; WO2007/108743; (2007); A2;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com