A common heterocyclic compound, the isothiazole compound, name is Isothiazole,cas is 288-16-4, mainly used in chemical industry, its synthesis route is as follows.,288-16-4
Compound 1 (20 g, 0.235 mol 1) was added to dry 100 ml of diethyl ether under stirring under nitrogen and then cooled to below 0 C, n-butyllithium (0.24 mol 1) was added dropwise thereto, 0 C or less, dropwise after completion of the incubation until no compound 1 is added.To the reaction solution was added dropwise bromine (0.5 mol), and the mixture was kept below 0 C during the dropwise addition. After the completion of the dropwise addition, the temperature was gradually raised to room temperature. After stirring for half an hour, the hydrochloric acid solution (2N, 500 ml) TheAnd the aqueous phase was extracted with ether (200 ml * 3) and discarded. The organic phase was combined and washed with sodium dithionite solution(100 ml * 2), dried over anhydrous sodium sulfate, filtered and concentrated to dryness to give compound 2 as a yellow oil.In this step, the ether can also be replaced with a solvent such as methyl ether, dimethyl ether, tetrahydrofuran, 1,4-dioxane and the like.
As the rapid development of chemical substances, we look forward to future research findings about 288-16-4
Reference£º
Patent; Tianjin Jinyao Group Co., Ltd.; Ge Yu; Li Yanfeng; (39 pag.)CN106892913; (2017); A;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com