New discoveries in chemical research and development in 2021, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 771-60-8, Name is 2,3,4,5,6-Pentafluoroaniline, SMILES is NC1=C(F)C(F)=C(F)C(F)=C1F, in an article , author is Boy, Kenneth M., once mentioned of 771-60-8, Product Details of 771-60-8.
The synthesis, evaluation, and structure-activity relationships of a class of acyl guanidines which inhibit the BACE-1 enzyme are presented. The prolinyl acyl guanidine chemotype (7c), unlike compounds of the parent isothiazole chemotype (1), yielded compounds with good agreement between their enzymatic and cellular potency as well as a reduced susceptibility to P-gp efflux. Further improvements in potency and P-gp ratio were realized via a macrocyclization strategy. The in vivo profile in wild-type mice and P-gp effects for the macrocyclic analog 21c is presented. (C) 2015 Elsevier Ltd. All rights reserved.
Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. If you are hungry for even more, make sure to check my other article about 771-60-8, Product Details of 771-60-8.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com