Chemical Research Letters, April 2021. Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 18621-17-5, Name is 1-Benzhydrylazetidin-3-ol, molecular formula is C16H17NO, Application In Synthesis of 1-Benzhydrylazetidin-3-ol, belongs to isothiazole compound, is a common compound. In a patnet, author is Nadirova, Maryana A., once mentioned the new application about 18621-17-5.
It was found that the reaction of 5-arylfurfurilamines with maleic anhydride leads to the formation of 6-aryl-3a,6-epoxyisoindole-7-carboxylic acids (the cyclic form), which in solution are in dynamic equilibrium with N-furfurylmaleinamides (the open form). During the esterification of these tautomeric mixtures with methanol in the presence of a catalytic amount of sulfuric acid, methyl esters of 5-aryl-7a-hydroxy-7-methoxy-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-isoindole-4-carboxylic acids, unexpected cleavage products of the 3a,6-oxo bridge of the cyclic form, are formed diastereospecifically. The structure of the obtained products was confirmed by X-ray structural analysis.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield. If you are hungry for even more, make sure to check my other article about 18621-17-5, Application In Synthesis of 1-Benzhydrylazetidin-3-ol.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com