New Advances in Chemical Research in 2021, Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media. 555-16-8, Name is 4-Nitrobenzaldehyde, molecular formula is C7H5NO3, belongs to isothiazole compound. In a document, author is Lu, Yuelie, introduce the new discover, Recommanded Product: 555-16-8.
A concise, scaleable synthesis of building block 10 for p38 kinase inhibitor B is described. The key step is the one-pot construction of 5-aryl-3-metbyl-2-methylsulfanyl-6-pyridin-4-yi-3H-pyrimidin-4-one 4 from arylacetic acid ethyl ester 1. Subsequent hydrolysis of the thiomethyl group to the hydroxy group and chlorination provided the key intermediate, 2-chloro-3-methyl-6-pyridin-4-yl-5-aryl-3Hpyrimidin-4-one 10. This class of reactive building blocks enabled the rapid evaluation of a variety of side chains at the 2-position of the pyrimidinone in SAR studies of inhibitors of p38 MAP kinase. (c) 2006 Elsevier Ltd. All rights reserved.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield. If you are hungry for even more, make sure to check my other article about 555-16-8, Recommanded Product: 555-16-8.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com