Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Soni, Sonam, once mentioned the application of 105-07-7, Name is 4-Cyanobenzaldehyde, molecular formula is C8H5NO, molecular weight is 131.13, MDL number is MFCD00003376, category is isothiazole. Now introduce a scientific discovery about this category, COA of Formula: C8H5NO.
Dithioester-enabled chernodivergent synthesis of acids, amides and isothiazoles via C-C bond cleavage and C-O/C N/C-S bond formations under metal- and catalyst-free conditions
An operationally simple and user-friendly process to access privileged scaffolds such as acids, amides and isothiazoles has been devised employing beta-ketodithioesters for the first time. Remarkably, the new protocol involves combination of C-C bond cleavage and C-O/C N/N-S bond formations in one-pot. Aqueous ammonia led to the formation of skeletally distinct amide and isothiazole, whereas aqueous NaOH enabled the formation of aromatic acid near quantitative yield. This practical approach, which can dramatically streamline the synthesis of simple molecules, is highly chemoselective, cost-effective, amenable to gram scale, insensitive to moisture as well as bears high functional group compatibility. (C) 2017 Elsevier Ltd. All rights reserved.
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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com