771-60-8, Name is 2,3,4,5,6-Pentafluoroaniline, molecular formula is C6H2F5N, Formula: C6H2F5N, belongs to isothiazole compound, is a common compound. In a patnet, author is Boy, Kenneth M., once mentioned the new application about 771-60-8.
Macrocyclic prolinyl acyl guanidines as inhibitors of beta-secretase (BACE)
The synthesis, evaluation, and structure-activity relationships of a class of acyl guanidines which inhibit the BACE-1 enzyme are presented. The prolinyl acyl guanidine chemotype (7c), unlike compounds of the parent isothiazole chemotype (1), yielded compounds with good agreement between their enzymatic and cellular potency as well as a reduced susceptibility to P-gp efflux. Further improvements in potency and P-gp ratio were realized via a macrocyclization strategy. The in vivo profile in wild-type mice and P-gp effects for the macrocyclic analog 21c is presented. (C) 2015 Elsevier Ltd. All rights reserved.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 771-60-8 help many people in the next few years. Formula: C6H2F5N.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com