Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 1719-19-3, Name is 2-Methyl-4-phenylbut-3-yn-2-ol, molecular formula is C11H12O. In an article, author is El Abdellaoui, Hassan,once mentioned of 1719-19-3, Category: isothiazole.
Identification of isothiazole-4-carboxamidines derivatives as a novel class of allosteric MEK1 inhibitors
The development of potent, orally bioavailable, and selective series of 5-amino-3-hydroxy-N(1-hydroxypropane-2-yl)isothiazole-4-carboxamidine inhibitors of MEK1 and MEK-2 kinase is described. Optimization of the carboxamidine and the phenoxyanifine group led to the identification of 55 which gave good potency as in vitro MEK1 inhibitors, and good oral exposure in rat. (c) 2006 Elsevier Ltd. All rights reserved.
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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com