Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 586-76-5, Name is 4-Bromobenzoic acid. In a document, author is WAMHOFF, H, introducing its new discovery. COA of Formula: C7H5BrO2.
EFFICIENT SYNTHESIS OF FUSED ISOTHIAZOLE C-NUCLEOSIDES .1. SYNTHESIS OF A 3-BETA-D-RIBOFURANOSYLISOTHIAZOLO[4,5-D]PYRIMIDIN-7(6H)-ONE ISOSTERE OF INOSINE
The reaction of 2-(2,3-O-isopropylidene-5-O-trityl-beta-D-ribofuranosyl)acetonitrile (6) with isopentyl nitrite/NaH and subsequent tosylation of Na-oximino nitrile 7 gave protected 2-D-ribofuranosyl-2-(tosyloximino)acetonitriles 9alpha,beta as novel C-nucleoside precursors. Treatment of 9alpha,beta with ethyl 2-mercaptoacetate under basic conditions afforded epimeric ethyl 4-aminoisothiazole-5-carboxylate C-nucleosides 10alpha,beta. Cyclization of 10alpha,beta to the desired 3-D-ribofuranosylisothiazolo[4,5-d]pyrimidin-7(6H)-ones 14alpha,beta was accomplished by the reaction of 10alpha,beta with triethyl orthoformate and subsequent amminolysis. Deprotection of 14beta and 14alpha in 7% HCl/MeOH gave the title compound 3 and alpha-isomeric C-nucleoside 4 as monohydrochloride salt, respectively. The configuration of C-glycoside 9alpha was established by X-ray crystallography.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 586-76-5 help many people in the next few years. COA of Formula: C7H5BrO2.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com