Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Name: 2-Bromo-4-chloro-6-nitrophenylamine827-25-8, Name is 2-Bromo-4-chloro-6-nitrophenylamine, SMILES is BrC1=C(C(=CC(=C1)Cl)[N+](=O)[O-])N, belongs to isothiazole compound. In a article, author is Chen, Lai, introduce new discover of the category.
Design, Synthesis and Biological Evaluation of Isothiazole Based 1,2,4-Trizaole Derivatives
A series of novel 3,4-dichloroisothiazole based 1,2,4-triazole derivatives were rationally designed and synthesized. Their structures were confirmed by H-1 NMR, C-13 NMR, HRMS or elemental analysis; the typical crystal structure was determined by X-ray diffraction for validation. All target compounds were evaluated for their in vitro fungicidal and in vivo anti-TMV activities. The bioassay results indicated that compound 6b, namely 1-(3,4-dichloroisothiazol-5-yl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol, exhibited excellent growth inhibition against B. cinerea, C. arachidicola and P. piricola with median effective concentrations (EC50) of 6.98, 2.73 and 3.07 g/mL, respectively, and good in vivo anti-TMV activity of over 60% of inactivation and induction activity at 100 g/mL. These data demonstrate that compound 6b is both a fungicide and an anti-TMV lead, deserving further studies.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 827-25-8. Name: 2-Bromo-4-chloro-6-nitrophenylamine.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com