Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.91-10-1, Name is 2,6-Dimethoxyphenol, SMILES is COC1=CC=CC(OC)=C1O, belongs to isothiazole compound. In a document, author is Fisher, Matthew J., introduce the new discover, Computed Properties of C8H10O3.
3-Phenyl-5-isothiazole carboxamides with potent mGluR1 antagonist activity
The disclosed 3-phenyl-5-isothiazole carboxamides are potent allosteric antagonists of mGluR1 with generally good selectivity relative to the related group 1 receptor mGluR5. Pharmacokinetic properties of a member of this series (1R,2R)-N-(3-(4-methoxyphenyl)-4-methylisothiazol-5-yl)-2-methylcyclopropanecarboxamide (14) are good, showing acceptable plasma and brain exposure after oral dosing. Oral administration of isothiazole 14 gave robust activity in the formalin model of persistent pain which correlated with CNS receptor occupancy. (C) 2012 Elsevier Ltd. All rights reserved.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 91-10-1. Computed Properties of C8H10O3.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com