With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.87691-88-1,3-Piperazinobenzisothiazole hydrochloride,as a common compound, the synthetic route is as follows.,87691-88-1
To a solution of 3- (1-piperazinyl) -1,2_ benzisothiazole hydrochloride (100g) and potassium carbonate (136g) in acetonitrile (800ml) added the suspension 1,4_ butanediol dimethyl sulfonate (lllg). Under vigorous stirring for 10 hours the resulting mixture was refluxed. After the solvent was distilled off under reduced pressure to acetonitrile was added, the reaction mixture was evaporated to clean water (100ml) and toluene (300ml), with stirring to break up the product mixture, refluxing under stirring operation, in addition to the net after the water, cool down, the suspension was filtered to give a white inorganic salts and organic salts of a mixture of the crude quaternary spiro ammonium base (272g).
The synthetic route of 87691-88-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Yantai Besten Pharmaceutical Co., Ltd.; Bi, Haidong; Zhang, Yifang; (8 pag.)CN105669665; (2016); A;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com