Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 122-75-8, Name is N1,N2-Dibenzylethane-1,2-diamine diacetate, SMILES is CC(O)=O.CC(O)=O.C1(CNCCNCC2=CC=CC=C2)=CC=CC=C1, belongs to isothiazole compound. In a document, author is GAROZZO, A, introduce the new discover, Quality Control of N1,N2-Dibenzylethane-1,2-diamine diacetate.
ANTIPOLIOVIRUS ACTIVITY OF ISOTHIAZOLE DERIVATIVES – MODE OF ACTION OF 5,5′-DIPHENYL-3,3′-DIISOTHIAZOLE DISULFIDE (DID)
In this report we describe the antiviral activity of 5,5′-diphenyl-3,3’diisothiazole disulfide (DID) and discuss its mode of action. DID selectively inhibits the replication of poliovirus type 1 (therapeutic index = 255) by affecting some early process of the virus growth cycle. The compound does not interfere with adsorption and internalization of virus to HEp-2 cells, nor with uncoating of the viral RNA. However, no viral RNA synthesis occurs after 2 h postinfection in the presence of 50 mu M DID. Thus, we investigated some molecular events in poliovirus replication occurring between uncoating and viral RNA synthesis. In our experimental design, we studied the activity of RNA polymerase complex isolated from HEp-2 infected cells in the presence or absence of DID. Our results showed that the RNA polymerase complex was formed in the presence of DID, On the contrary, DID markedly inhibited poliovirus RNA synthesis in a cell-free system using RNA polymerase complex isolated from infected cells. These findings indicate that DID may exert its antiviral activity by preventing viral RNA chain elongation via the inhibition of replicase activity and/or interfering with viral RNA polymerase complex.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 122-75-8 is helpful to your research. Quality Control of N1,N2-Dibenzylethane-1,2-diamine diacetate.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com