Chemistry, like all the natural sciences, Formula: C9H8O, begins with the direct observation of nature¡ª in this case, of matter.1504-58-1, Name is 3-Phenylprop-2-yn-1-ol, SMILES is OCC#CC1=CC=CC=C1, belongs to isothiazole compound. In a document, author is Moon, Sanghun, introduce the new discover.
Synthesis of Isothiazoles and Isoselenazoles through Rhodium-Catalyzed Oxidative Annulation with Elemental Sulfur and Selenium
A rhodium-catalyzed oxidative annulation of benzimidates with elemental sulfur for the direct construction of isothiazole rings is reported. The proposed reaction mechanism involving Rh(I)/Rh(III) redox is supported by a stoichiometric reaction of metallacycle species as well as DFT calculations. This method is also applicable to selenium cyclization to produce isoselenazole derivatives. The alkoxy substituent at C3 can be used for further functionalization of the azole core.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 1504-58-1. Formula: C9H8O.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com