87691-88-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3-Piperazinobenzisothiazole hydrochloride, cas is 87691-88-1,the isothiazole compound, it is a common compound, a new synthetic route is introduced below.
N- [4- (2-CHLORO-ETHYL)-2-METHYL-PHENYL]-N-METHYL-ACETAMIDE (0.300 g, 1. 153 mmol), 3-PIPERAZIN-1-YL-BENZO [d] isothiazole hydrochloride (0.442 g, 1.729 MMOL), potassium carbonate (0.237 g, 1.729 MMOL), and potassium iodide (0.173 g, 1.153 MMOL) in ACETONITRILE (3.5 mL) was subjected to 150 C for 30 min. under microwave assistance using a Smith Personal Chemistry microwave. The reaction was diluted with H20 (50 mL) and CH2CI2 (100 mL). The layers were separated and the organics washed with 1 N HCI (2x 25 mL). The aqueous layer was made basic and extracted with CH2CI2 (3X50 mL). The organics were dried (MGS04), and concentrated to a solid residue. The residue was subjected to chromatography (MEOH : CH2CI2 1 : 19) and collected as an amorphous residue and taken up in 1,4-dioxane and subjected to HCI gas for 10 min. The resulting solid was collected by filtration and dried at 50 C under high vacuum overnight (0.770 g). 100% purity at 254nm; LCMS (APCI) : 409.2 [M+H] +.
The chemical industry reduces the impact on the environment during synthesis,87691-88-1,3-Piperazinobenzisothiazole hydrochloride,I believe this compound will play a more active role in future production and life.
Reference£º
Patent; WARNER-LAMBERT COMPANY LLC; WO2004/41793; (2004); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com