24340-77-0, 4-Bromoisothiazole is a isothiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
n-Butyllithium (2.5 M solution in hexanes, 10.5 mL, 26.2 mmol) was added to a-78 00 solution of diisopropylamine (3.68 mL, 26.3 mmol) in tetrahydrofuran (80 mL).After 30 minutes, a solution of 4-bromo-1 ,2-thiazole (3.70 g, 22.5 mmol) intetrahydrofuran (20 mL) was added drop-wise, and stirring was continued at -78 00 for 30 minutes, whereupon methyl carbonocyanidate (99%, 2.15 mL, 26.8 mmol) was added. After an additional 30 minutes at -78 00 the reaction mixture was quenched via addition of saturated aqueous ammonium chloride solution, and the resulting mixturewas warmed to room temperature. After dilution with water, it was extracted with ethyl acetate; the combined organic layers were washed with saturated aqueous sodium chloride solution, dried over magnesium sulfate, filtered, and concentrated in vacuo. Purification via silica gel chromatography (Eluent: 5% ethyl acetate in heptane) provided the product as a white solid. Yield: 4.0 g, 18 mmol, 80%. 1H NMR (400 MHz, ODd3) oe8.43 (5, 1H), 3.97 (5, 3H)., 24340-77-0
The synthetic route of 24340-77-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PFIZER INC.; GRAY, David Lawrence Firman; ZHANG, Lei; DAVOREN, Jennifer Elizabeth; DOUNAY, Amy Beth; EFREMOV, Ivan Viktorovich; MENTE, Scot Richard; SUBRAMANYAM, Chakrapani; WO2015/162515; (2015); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com