288-16-4, Name is Isothiazole, belongs to isothiazole compound, is a common compound. Computed Properties of C3H3NSIn an article, once mentioned the new application about 288-16-4.
Synthesis and biological activity of novel comenic acid derivatives containing isoxazole and isothiazole moieties
Methyl 5-hydroxy-4-oxo-4H-pyran-2-carboxylate was synthesized by esterification of methanol with comenic acid under acidic catalysis. The obtained ester was alkylated with 3-(chloromethyl)-5-phenylisoxazole and 4,5-dichloro-3-(chloromethyl)isothiazole to afford corresponding conjugates containing isoxazole and isothiazole moieties which then were transformed into water-soluble Li-salts. During the bioassays of synthesized isoxazole and isothiazole derivatives of comenic acid in mixtures with first-line antitumor drug Temobel (Temozolomid) used in brain tumors chemotherapy, a synergetic effect was observed.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Computed Properties of C3H3NS, you can also check out more blogs about288-16-4
Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com