288-16-4, Name is Isothiazole, belongs to isothiazole compound, is a common compound. COA of Formula: C3H3NSIn an article, once mentioned the new application about 288-16-4.
Synthesis, in vitro alpha-glucosidase inhibitory activity, and in silico study of (E)-thiosemicarbazones and (E)-2-(2-(arylmethylene)hydrazinyl)-4-arylthiazole derivatives
This study is focused on the identification of thiazole-based inhibitors for the (Formula presented.)-glucosidase enzyme. For that purpose, (E)-2-(2-(arylmethylene)hydrazinyl)-4-arylthiazole derivatives were synthesized in two steps and characterized by various spectroscopic techniques. All derivatives and intermediates were evaluated for their in vitro (Formula presented.)-glucosidase inhibitory activity. Thiosemicarbazones 20 and 35, and cyclized thiazole derivatives 2, 5?11, 13, 15, 21?24, 27?31, and 36?37 showed significant inhibitory potential in the range of (Formula presented.)?(Formula presented.) as compared to standard acarbose ((Formula presented.)). A molecular modeling study was carried out to understand the binding interactions of compounds with the active site of enzyme.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 288-16-4 is helpful to your research. COA of Formula: C3H3NS
Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com