Synthetic Route of 4576-90-3, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. Synthetic Route of 4576-90-3, Name is Isothiazole-3-carboxylic acid, molecular formula is C4H3NO2S. In a Article, authors is Nakai, Takashi£¬once mentioned of Synthetic Route of 4576-90-3
Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans
In recent years, soluble guanylate cyclase (sGC, EC 4.6.1.2) has emerged as an attractive therapeutic target for treating cardiovascular diseases and diseases associated with fibrosis and end-organ failure. Herein, we describe our design and synthesis of a series of 4-hydroxypyrimidine sGC stimulators starting with an internally discovered lead. Our efforts have led to the discovery of IWP-051, a molecule that achieves good alignment of potency, stability, selectivity, and pharmacodynamic effects while maintaining favorable pharmacokinetic properties with once-daily dosing potential in humans.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Synthetic Route of 4576-90-3, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 4576-90-3, in my other articles.
Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com