Electric Literature of 107869-45-4, Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about Electric Literature of 107869-45-4
Chemistry of Oxaziridines. 18. Synthesis and Enantioselective Oxidations of the <(8,8-Dihalocamphoryl)sulfonyl>oxaziridines
The synthesis and enantioselective oxidations of <(8,8-dihalocamphoryl)sulfonyl>oxaziridines 13 are reported.These reagents are prepared in two steps from the (camphorylsulfonyl)imine 4 by treatment of the corresponding azaenolate with electrophilic halogen sources followed by biphasic oxidation of the resulting dihalo imine 6-9 with m-CPBA/K2CO3.Of these oxaziridines the dichloro reagent 13b, available on a multigram scale, affords the highest enantioselectivities for the asymmetric oxidation of sulfides to sulfoxides (42-74 percent) and for the hydroxylation of enolates (often better than 95 percent ee).In general the molecular recognition is predicted and explained in terms of minimization of nonbonded steric interactions in the transition states.For the asymmetric oxidation of sulfides to sulfoxides, secondary electronic factors related to the polarity of the sulfide and oxaziridine also play a role.Definitive evidence for chelation of the metal enolate with the C-X bond in 13 is not found.The molecular recognition is interpreted in terms of the higher reactivity of the reagents and an active-site structure which is sterically complementary with the enolate.For the asymmetric hydroxylation of the Z- and E-enolates of propiophenone (16a), the Z-enolate exhibits much higher stereoselectivity than the E-enolate: >95 percent vs 22 percent ee.
Electric Literature of 107869-45-4, If you are hungry for even more, make sure to check my other article about 107869-45-4
Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com