Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, the author is Baranokova, Michaela and a compound is mentioned, SDS of cas: 272-16-2, Benzo[d]isothiazole, introducing its new discovery. SDS of cas: 272-16-2
Recent progress in the discovery and development of DNA gyrase B inhibitors
New antibacterials that modulate less explored targets are needed to fight the emerging bacterial resistance. DNA gyrase and topoisomerase IV are attractive targets in this search. These are both type II topoisomerases that can cleave both DNA strands, and can thus alter DNA topology during replication or similar processes. Currently, there are no ATP-competitive inhibitors of these two enzymes on the market, as the only aminocoumarin representative, novobiocin, was withdrawn due to safety concerns. The search for novel ATP-competitive inhibitors is a focus of ongoing industrial and academical research. This review summarizes the recent efforts in the design, synthesis and evaluation of GyrB/ParE inhibitors. The various approaches to achieve improved antibacterial activities are described, with particular reference to Gram-negative bacteria.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 272-16-2, help many people in the next few years.SDS of cas: 272-16-2
Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com