Synthetic Route of 27148-03-4, In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, Synthetic Route of 27148-03-4, name is Benzo[d]isothiazole-3(2H)-thione 1,1-dioxide, introducing its new discovery.
Pseudosaccharin amine derivatives: Synthesis and elastase inhibitory activity
Pseudosaccharin amines were synthesized from saccharin either by the reaction of pseudosaccharin chloride with amines, or via thiosaccharin which was treated with amines yielding thiosaccharinates, and their reaction with glacial acetic acid. This route gave lower yields than the first way. The synthesis of alkyl [(1,1-dioxo-benzo[d]isothiazol-3-yl)amino]alkanoates as possible Human Leukocyte Elastase (HLE) inhibitors was realized by the reaction between amino acid esters and pseudosaccharin chloride. Hydrolysis of the esters was possible under aqueous basic conditions. Selected compounds were screened for elastase inhibitory activity. Compounds 4k and 4m were found to be reversible inhibitors of HLE with Ki values of 45 muM and 60 muM.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Synthetic Route of 27148-03-4, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 27148-03-4, in my other articles.
Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com