Identification of fungi from children’s shoes and application of a novel antimicrobial agent on shoe insole was written by Li, Hui;Zhou, Jin;Shi, Rui;Chen, Wuyong. And the article was included in African Journal of Biotechnology in 2011.Application In Synthesis of Isothiazol-3(2H)-one This article mentions the following:
Thirteen strains of fungi were isolated from 12 shoes worn by children aged 6-12 for a period of more than half a year consisting of 5 strains of yeasts and 8 strains of molds. Through morphol. observation and 18S rDNA sequence anal., the 5 strains of yeasts were identified as follows: Cryptococcus neoformans, Candida albicans, Cryptococcus albidus, Rhodotorula mucilaginosa, and Candida utilis. While the 8 strains of molds characterized and classified by point cropping, insert method, and imprint method were resp. Mucor (2 subspecies), Chain cell mold, Aspergillus (3 subspecies), and Penicillium (2 subspecies). In order to protect children’s feet from being infected by the fungi, a novel nano antimicrobial composite containing nano ZnO and isothiazolinone was prepared and was used to treat the children’s insole by spraying. The inhibitory effects of the nano antimicrobial composite treated insole against yeasts and molds from children’s shoes were evaluated by the inhibition zone and the inhibition ratio method. The results show that the insole treated with 2% nano antimicrobial composite could inhibit the growth of tested microorganism effectively, which could also achieve >97% inhibition ratio against the entire tested fungi. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Application In Synthesis of Isothiazol-3(2H)-one).
Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Isothiazoles and isothiazolium cations are attacked by carbanions at sulfur and on recyclization can give thiophenes. Various penicillins and cephalosporins having an isothiazole ring system have shown considerable antibacterial efficacy against Gram-positive and Gram-negative bacteria.Application In Synthesis of Isothiazol-3(2H)-one
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com