Conjugate addition of the phenyldimethylsilyl group to αβ-unsaturated carbonyl compounds using a silylzincate in place of the silylcuprate was written by Crump, Roger A. N. C.;Fleming, Ian;Urch, Christopher J.. And the article was included in Journal of the Chemical Society, Perkin Transactions 1 in 1994.Recommanded Product: (E)-1-((3aR,6S,7aS)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)but-2-en-1-one This article mentions the following:
Li phenyldimethylsilyl(dialkyl)zincates add to a number of αβ-unsaturated carbonyl compounds,e.g., PhC:CHCO2Me, to give, in most cases, higher yields of the conjugate addition product, e.g., PhMe2SiCHPhCH2CO2Me, than the authors had achieved with the corresponding silylcuprate. In the experiment, the researchers used many compounds, for example, (E)-1-((3aR,6S,7aS)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)but-2-en-1-one (cas: 94594-81-7Recommanded Product: (E)-1-((3aR,6S,7aS)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)but-2-en-1-one).
(E)-1-((3aR,6S,7aS)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)but-2-en-1-one (cas: 94594-81-7) belongs to isothiazole derivatives. Similar to other five-membered heterocycles, isothiazoles react with a wide range of electrophilic and nucleophilic reagents to form diverse products. The ring structure of isothiazole is incorporated into larger compounds with biological activity such as the pharmaceutical drugs ziprasidone and perospirone.Recommanded Product: (E)-1-((3aR,6S,7aS)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)but-2-en-1-one
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com