Simultaneously detecting chlorophenols and isothiazolinones in food contact paper packaging materials using ultrahigh-performance liquid chromatography tandem mass spectrometry was written by Zhang, Cong;Huang, Jin-feng;Cai, Wei-hong;Li, Xiu-ying;Guo, Xin-dong;He, Min-heng;Feng, Xiang. And the article was included in Xiandai Shipin Keji in 2015.Safety of Isothiazol-3(2H)-one This article mentions the following:
A comprehensive anal. method was developed to simultaneously detect chlorophenols and isothiazolinones (Ml, CMI, BIT, 2,4-DCP, 2,4,6-TCP, 2,3,4,6-TCP, PCR and OPP) in food contact paper packaging materials using ultra-performance liquid chromatog.-tandem mass spectrometry (UPLC-MS/MS) and solid phase extraction (SPE). The paper samples were subjected to ultrasonic methanol extraction, concentrated, and purified with an Oasis HLB SPE cartridge. The extract was separated in a Phenomenex Kinetex C18 column (100 mm × 3.0 mm, 2.6μm) using gradient elution with a methanol-water mobile phase. The MS/MS anal. was performed in electrospray ionization mode with multiple reaction monitoring (MRM) and separated into two segments of pos. and neg. ionization modes. Eight compounds were identified by retention lime and the ratio of characteristic ions, and these were quantified using the external standard methods. Under optimal conditions, the calibration curves for the eight analytes were linear within the range of 2.0 to 400μg/L, with correlation coefficients more than 0.997. The quantitation limits of the method (S/N = 10) for the eight compounds were 10 to 30μg/kg. The mean recoveries for paper samples at spiked concentration levels of 10 to 300μg/kg were between 80.3% and 107%, while the relative standard deviations (RSDs, n = 6) ranged from 3.5% to 9.3%. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Safety of Isothiazol-3(2H)-one).
Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Isothiazole is more toxic than pyridine. But the more substituted isothiazoles are usually far less toxic. The ring structure of isothiazole is incorporated into larger compounds with biological activity such as the pharmaceutical drugs ziprasidone and perospirone.Safety of Isothiazol-3(2H)-one
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com