Stereoselective synthesis of a conformationally restricted β-hydroxy-γ-amino acid was written by Xiao, Dong;Carroll, Patrick J.;Mayer, Scott C.;Pfizenmayer, Amy J.;Joullie, Madeleine M.. And the article was included in Tetrahedron: Asymmetry in 1997.Safety of 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one This article mentions the following:
β-Hydroxy-γ-amino acids are a class of non-proteinogenic amino acids present in many important biol. active natural products. In conjunction with the author’s research on didemnins, sterically constrained β-hydroxy-γ-amino acid I was designed and synthesized in which the requisite carboxyl, hydroxyl and amino groups are positioned on a conformationally stable 6-membered ring. In the experiment, the researchers used many compounds, for example, 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 94594-91-9Safety of 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one).
1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 94594-91-9) belongs to isothiazole derivatives. Similar to other five-membered heterocycles, isothiazoles react with a wide range of electrophilic and nucleophilic reagents to form diverse products. The isothiazoles can be oxidized to the corresponding sulfoxides on treatment with peracids.Safety of 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com