The critical review of methodologies and approaches to assess the inherent skin sensitization potential (skin allergies) of chemicals. Part III was written by Thyssen, Jacob P.;Gimenez-Arnau, Elena;Lepoittevin, Jean-Pierre;Menne, Torkil;Boman, Anders;Schnuch, Axel. And the article was included in Contact Dermatitis in 2012.Formula: C3H3NOS This article mentions the following:
The statistical evidence on the incidence and morbidity of skin contact allergy (contact dermatitis) cases in the European Union before and after the safety limits were set is presented. The evidence is used to assess the possible effect of the limits in the reduction/prevention of the incidence and morbidity of contact dermatitis. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Formula: C3H3NOS).
Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Isothiazoles and isothiazolium cations are attacked by carbanions at sulfur and on recyclization can give thiophenes. Many compounds with an isothiazole scaffold demonstrated a wide range of biological profiles. Some of these molecules have been efficiently used in the treatment of Alzheimer’s disease.Formula: C3H3NOS
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com